![]() ![]() It is widely noted that the dysregulation of stress proteins is associated with a variety of human diseases, including cardiovascular diseases, neurodegenerative diseases (e.g., Parkinson’s diseases, Alzheimer disease), stroke, human cancers and infectious diseases. Responses triggered by SPs can either activate pathways to promote cell survival or initiate cell death (i.e., apoptosis, necrosis, pyroptosis or autophagic cell death) for eliminating the damaged cells to protect a particular organ/tissue under given conditions. 1 SPs are ubiquitously expressed in all kind of cells, triggering signal cascades for neutralizing and eradicating the stresses occurring both intracellularly (e.g., pathogen invasion) and extracellularly (e.g., starvation, stimulation by cytokines/chemokines or hormones). Stress proteins include heat shock proteins (HSPs), RNA chaperone protein (RNPs), and proteins mainly function in the endoplasmic reticulum (ER): peptidyl-propyl isomerases, protein disulfide isomerases (PDIs) and the lectin-binding chaperone system. They exhibit protective effects against stresses. Stress proteins (SPs) are a diverse group of proteins that are synthesized at increased levels when cells are exposed to either intracellular or extracellular stressful stimuli. As SPs also attract a great interest as potential antiviral targets (e.g., COVID-19), we also discuss the present progress and challenges in this area of HSP-based drug development, as well as with compounds already under clinical evaluation. In this review, we summarized the biologic function of stress proteins, and current progress on their mechanisms related to virus reproduction and diseases caused by virus infections. Dysregulation of stress proteins is associated with many human diseases including human cancer, cardiovascular diseases, neurodegenerative diseases (e.g., Parkinson’s diseases, Alzheimer disease), stroke and infectious diseases. hnRNPs involve in a large number of cellular processes, including chromatin remodelling, transcription regulation, RNP assembly and stabilization, RNA export, virus replication, histone-like nucleoid structuring, and even intracellular immunity. RNA chaperones are a group of heterogeneous nuclear ribonucleoproteins (hnRNPs), which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase II. Regarded as a double-edged sword, HSPs also cooperate with numerous viruses and cancer cells to promote their survival. The major functions of HSPs include chaperoning misfolded or unfolded polypeptides, protecting cells from toxic stress, and presenting immune and inflammatory cytokines. Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. ![]()
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![]() In Book V, Chapter II of The Wealth of Nations, he wrote: "In the University of Oxford, the greater part of the public professors have, for these many years, given up altogether even the pretence of teaching." Smith considered the teaching at Glasgow to be far superior to that at Oxford, which he found intellectually stifling. In 1740, he was the graduate scholar presented to undertake postgraduate studies at Balliol College, Oxford, under the Snell Exhibition. Here he developed his passion for the philosophical concepts of reason, civilian liberties, and free speech. Smith entered the University of Glasgow at age 14 and studied moral philosophy under Francis Hutcheson. He attended the Burgh School of Kirkcaldy-characterised by Rae as "one of the best secondary schools of Scotland at that period" -from 1729 to 1737, he learned Latin, mathematics, history, and writing. ![]() Smith was close to his mother, who probably encouraged him to pursue his scholarly ambitions. The date of Smith's baptism into the Church of Scotland at Kirkcaldy was 5 June 1723 and this has often been treated as if it were also his date of birth, which is unknown.Īlthough few events in Smith's early childhood are known, the Scottish journalist John Rae, Smith's biographer, recorded that Smith was abducted by Romani at the age of three and released when others went to rescue him. Two months before Smith was born, his father died, leaving his mother a widow. Smith's mother was born Margaret Douglas, daughter of the landed Robert Douglas of Strathendry, also in Fife she married Smith's father in 1720. His father, also Adam Smith, was a Scottish Writer to the Signet (senior solicitor), advocate and prosecutor (judge advocate) and also served as comptroller of the customs in Kirkcaldy. Smith was born in Kirkcaldy, in Fife, Scotland. Smith was controversial in his own day and his general approach and writing style were often satirised by writers such as Horace Walpole. In this and other works, he developed the concept of division of labour and expounded upon how rational self-interest and competition can lead to economic prosperity. The Wealth of Nations was a precursor to the modern academic discipline of economics. In his later life, he took a tutoring position that allowed him to travel throughout Europe, where he met other intellectual leaders of his day.Īs a reaction to the common policy of protecting national markets and merchants, what came to be known as mercantilism-nowadays often referred to as "cronyism" or " crony capitalism" -Smith laid the foundations of classical free market economic theory. ![]() Smith obtained a professorship at Glasgow, teaching moral philosophy and during this time, wrote and published The Theory of Moral Sentiments. ![]() After graduating, he delivered a successful series of public lectures at the University of Edinburgh, leading him to collaborate with David Hume during the Scottish Enlightenment. Smith studied social philosophy at the University of Glasgow and at Balliol College, Oxford, where he was one of the first students to benefit from scholarships set up by fellow Scot John Snell. Among other economic theories, the work introduced Smith's idea of absolute advantage. Smith refuses to explain the distribution of wealth and power in terms of God's will and instead appeals to natural, political, social, economic and technological factors and the interactions between them. The latter, often abbreviated as The Wealth of Nations, is considered his magnum opus and the first modern work that treats economics as a comprehensive system and as an academic discipline. Seen by some as "The Father of Economics" or "The Father of Capitalism", he wrote two classic works, The Theory of Moral Sentiments (1759) and An Inquiry into the Nature and Causes of the Wealth of Nations (1776). Adam Smith FRSA (baptised 16 June 1723 – 17 July 1790) was a Scottish economist and philosopher who was a pioneer in the thinking of political economy and key figure during the Scottish Enlightenment. ![]() ![]() There are a wide variety of sizes and models for both commercial and home purposes. Some vacuum cleaners have dustbags, and others use a cyclone, which holds the debris and particles for later disposal. How Does a Vacuum Cleaner Work?Įxplaining how a vacuum cleaner works aren’t too complicated, although it does help to know the functionality of some of the items involved, and we do need to look inside the vacuum cleaner. ![]() Kenney invented the vacuum cleaners using suction. In 1901, British engineer Hubert Cecil Booth and American inventor David T. The modern vacuum cleaner, as we know it, with the suction and dustbag, was invented towards the end of the 19th century. Despite it being inconvenient to operate, it was marketed well, and so it sold well. McGaffey worked on the Whirlwind, a bulky and awkward device that actually required manual, crank-by-hand operation of the belt-driven fan. The rotating brush gathered dust, and the installed bellows generated suction.īefore that, Ives W. In 1860, Daniel Hess invented the first known manual vacuum cleaner known as the Carpet Sweeper. ![]() If you want to know exactly who invented the vacuum cleaner, it will take some searching through the archives as you’ll come across a few different types and names. To get an idea of what vacuum cleaner would suit your needs best, we need to go back in time a bit to understand how it all started. Using suction, it collects particles, dust, and debris from floors and other surfaces. Simply put, a vacuum cleaner is an electrical machine with a specific purpose. If you’ve just moved into your own place, if you’re looking for the perfect gift for someone, or if you’ve been using vacuum cleaners your entire life without knowing exactly what makes something a vacuum cleaner, then I’ll clear it up for you. Vacuum Buying Guide 2021 What is a Vacuum Cleaner?
![]() ![]() Below, let’s take an in-depth look at some of the common questions we receive regarding how to smoke shatter: Q: Can You Eat Shatter?Ī. While there are plenty of ways to consume shatter, eating it is not an effective form of ingestion, and we don’t recommend this method. We receive a lot of questions from readers about this unique cannabis concentrate. Read the instructions included with your vape pen and make sure that the pen’s manufacturer specifically says it’s suitable because some vape pens are not compatible. With most pens, you will need to add it to a compartment and then push a button – it’s that simple. If you want to know how to smoke shatter in a vape pen, it will depend on the type you purchase. While most vape pens are for cannabis oil, you can also smoke shatter, and other cannabis concentrates if you have the right type of vape- and it doesn’t require nearly as much effort as traditional dabs. Vape pens have emerged as a popular tool for various concentrates. If you don’t have the right materials, this method won’t be possible. If you want to dab, it’s critical to create a checklist of everything you need. As you’ll see, when you use your rig, it’s critical to use the dome to avoid losing the vapour (even if you inhale immediately).Īlthough it seems like a small amount of vapour that’s created from the shatter, it’s incredibly potent. The dome is used to ensure that the vapour doesn’t escape when it first touches the nail. Once the dome is securely placed over the nail, slowly dab the shatter onto the nail using the dabber.Once your nail is red hot, wait a few seconds and place the dome over the top of the nail.Turn your butane torch on and begin to heat the nail – the nail will get hot as you heat it up.This piece should be as small as possible. Start by placing a piece of shatter at the end of your dabber.Let’s take a step-by-step look at the dabbing process below: You’ll also need a nail, butane torch, and metal dabber. The only downside is that it requires additional hardware and a bit of practice.ĭabbing requires you to buy a ‘rig.’ A rig consists of a water pipe with a bulb-like dome or carb cap. ![]() ‘Dabbing’ is probably the most popular way to use cannabis concentrates- and shatter is no exception! If you’re looking for a quick, potent method of consumption, this is one of your best options. ![]() Make sure that you’re comfortable with shatter before adding too much to your bowl because the high will be much more intense. Make sure to adequately light the shatter as you smoke it.Ĭheck out different types of bongs to use.Īgain, this is another way to intensify the high you receive from a pipe or bong. Some people will add a bit more flower on top to fill out the bowl and help ensure a more consistent burn. So, let’s learn how to smoke shatter in a pipe or bong!įirst, place a layer of ground cannabis within your bong or pipe bowl, and then sprinkle the shatter on top. Smoking Shatter in a Pipe or Bongįor those who use glass pipes or bongs, you’ll be pleased to know that cannabis concentrates are compatible with both methods. If you don’t know how to roll a joint, you can always purchase a joint roller that automates the process. Next, sprinkle some crumbled shatter onto the flower and roll it as usual. Start by grinding your favourite cannabis strain and fill your rolling paper the way you usually would. If you’re someone who enjoys joints but wishes they were a bit stronger, rolling shatter in a joint could become one of your new favourite ways to smoke it! The most common way to smoke shatter is via a ‘dab rig’, but if you don’t have a rig, we’ll show you how to smoke shatter without one. While cannabis concentrates are readily accessible across Canada, you might not know how to smoke shatter yet. In this article, we’ll be taking a closer look at everything you need to know about it- and we’ll answer all your questions on how to smoke shatter. Many people are unaware of this unique cannabis concentrate and how to use it. In most cases, it will have the same appearance as a dark honey product, and its consistency is hard and brittle. So, what is shatter? It’s a high-grade concentrate that is similar to wax – some people say it looks like dry tree sap. This is a cannabis concentrate that is growing increasingly popular throughout Canada, and with THC levels that can reach above 90%, it’s not hard to see why. ![]() ![]() ![]() Please click each link below to find the idea:ĭownload this grateful for printable in color and black and white. If you love these Thanksgiving Coloring Pages, you’re going to love these other Thanksgiving ideas. Even though this seems like it could be just for kids, it was therapeutic for me to write and draw. One person on your team is designated to be the first person to draw a picture of whatever random Pictionary word is. I know how important it is to count my blessings and needed a way to write it all down. Looking for Thanksgiving coloring pages to keep your little ones entertained while you prepare your holiday feast Here you'll find a huge collection of coloring sheets from cute turkeys and abundant cornucopias to intricately-patterned pictures for big kids and adults to color in too. Below are coloring pages, word puzzles, mazes, hidden pictures, picture matching, and connect the dot activity pages. I had lost my Dad to cancer, was in the thick of tough time as an autism mom and just couldn’t shake the hard stuff. I was having a really tough time with things happening around me. When I created this a couple years ago, I really felt the need to spend some time writing down what I was grateful for. You'll find Thanksgiving coloring pages of turkeys, pumpkins, ships, cornucopias, and Thanksgiving dinner. Printable Activity Placements Instant Download bundle. 01 of 11 Thanksgiving Coloring Pages Primary Games There are a few Thanksgiving coloring pages here that your child will have a blast coloring. 4.17 (15 off) Thanksgiving Kids Coloring Placemats pack of 5. The color version has some cute colors for the fall. 30 Thanksgiving Coloring Pages for Kids Autumn Coloring Pages for Kids Thanksgiving Coloring Pages Halloween Coloring Fall Coloring. ![]() There’s a black and white version that kids can color in if they want (or the adults can too!). With this printable, you can have adults or kids print it out and fill in. I can’t believe that it’s time for Thanksgiving this week and knew I needed to update this design. Help your holidays be more meaningful with these Thanksgiving Coloring Pages! Print some out and focus on what you’re grateful for.Ī couple years ago I created an “ I’m Grateful for…” Thanksgiving coloring pages for people to fill in. ![]() ![]() In the end, what stood out to Wang and her colleagues most was a noticeable tendency toward reciprocal, eye-for-an-eye forms of retaliation across all the different aspects of misconduct they studied. The researchers weren't sure what patterns would emerge but expected to see a mixture of escalation, de-escalation, and reciprocation, depending on the circumstance. For instance, they could find out if severe misconduct, like sexual harassment, was more likely to yield an escalating response than mild misconduct, like gossiping or if highly active forms of demeaning behavior, like bullying from a boss, might yield more passive responses, such as calling in sick. They also looked at the target of the behavior-whether it was directed back at the original instigator or displaced onto someone else ("you hurt me and I kick my dog," as Wang describes it).Īnalyzing these dimensions separately allowed the researchers to develop a nuanced portrait of negative workplace behavior and its aftermath. The team sorted the data from these published studies into groups, determining whether each behavior was mild, moderate, or severe, as well as whether it was passive (e.g., not showing up for work), active (e.g., screaming at a colleague), or a bit of both (e.g., griping with coworkers behind the boss's back). The researchers only analyzed cases where more than one person was involved and where they could identify a clear target, whether that target was another person (as in cases of bullying or sabotage) or the organization itself (as in cases of absenteeism or workplace theft).įor each instance of negative behavior, the researchers were also able to determine whether an individual was the perpetrator or the target of the behavior, since this information had been captured by the original studies they aggregated. In the end, the team's sample, drawn from 207 studies (most of which collected data via surveys), included nearly 97,000 individuals and represented a diverse pool of industries, including healthcare, the service sector, and government. This involved trawling through hundreds of journal articles about workplace misconduct and identifying the ones that captured usable information about negative workplace behavior by one party and how another party responded. Whitson of the University of California, Los Angeles. ![]() O'Boyle of Indiana University, Joongseo Kim of Pennsylvania State University–Erie, and Jennifer A. Greco of Oklahoma State University, Ernest H. To find out, Wang teamed up with Lindsey M. The researchers hoped to shed light on a long-standing debate in their field: when people are treated poorly, do they respond in kind ("an eye for an eye"), do they escalate the bad behavior, or do they try to de-escalate and wind it down? Wang and her colleagues wanted to capture that broader social context and understand how the targets of workplace behavior respond to a provocation. ![]() It involves at least two people: if there's a bully at the office, there's also someone being bullied. Yet in reality, some of the most intractable workplace misconduct isn't a solitary pursuit. These studies have mostly focused on individuals, identifying personality or attitudinal trends among the bad apples who perpetrate the offenses. ![]() There is a lot of existing research on so-called negative workplace behavior, a category that includes severe misconduct, like sexual harassment, and more quotidian transgressions, like browsing Amazon when you should be finishing a project. Account icon An icon in the shape of a person's head and shoulders. ![]() ![]() ![]() For example, all rectangles have four right angles and squares are rectangles, so all squares have four right angles. Geometric shapes Piet Mondrian is an excellent example of an artist who used geometric shapes almost exclusively. ![]() This work of art by Alexander Calder includes both geometric and biomorphic forms. Sculpture is the most obvious place to see form, or three-dimensional shape, in art. The geometric shape definition in art is characterized by a reliance on mathematical shapes such as triangles, squares, circles, and lines to organize space. Biomorphic shapes are often rounded and irregular, and can also turn into forms. Understand that attributes belonging to a category of two-dimensional figures also belong to subcategories of that category. The term biomorphic means: life-form (biolife and morph form). *10.a Apply formal and conceptual vocabularies of art and design to view surroundings in new ways through art-making. 8.a Interpret art by analyzing characteristics of form and structure, contextual information, subject matter, visual elements, and use of media to identify ideas and mood conveyed.Students identify attributes of shapes and parts of shapes in pattern blocks. Instead of regular, precise edges, these shapes. Spiral Triangles Create a spiral design using equilateral triangles To create the design, start out with a large triangle. Lesson Description (Use for family communication and displaying student art). They look more like shapes found in nature, such as plants and animals. 7.1.a Compare one’s own interpretation of a work of art with the interpretation of others. In the following activities, students use geometry vocabulary and explore math concepts including: measurement, area and perimeter, fractions and patterns 1.2.1.a Experiment and develop artistic ideas and work.See more ideas about art lessons, elementary art, shape art. 1.2.a Identify and demonstrate diverse methods of artistic investigation to choose an approach for beginning a work of art. Explore Mary Batsons board 'Shape Art Lesson', followed by 797 people on Pinterest.It is a study that compares these different types of objects and their relationships. Download this transparent Blobs Vector Collection Or Organic Shapes Free Download, Blobs, Organic Shapes, Splash Vector PNG image and clipart for free. 1.1.a Combine ideas to generate an innovative idea for artmaking. Geometry is a subject in math that deals with shapes, lines, points, and 3-D objects.Instructional Video Learning Standards Arts GLEs Photos courtesy of the Tacoma Art Museum and the Northwest Museum of Art and Culture. ![]() ![]() Send some pizzazz to your loved one with this stylish bouquet Shown at 70.00 Buy Now SUN-KISSED COUNTRY 80.00 Buy Now RED ROSES AND WISPY WHITES 90. there are so many in my library but if i had to narrow down some favorites, they'd be Dateline (lol) Something Was Wrong, and Crime Junkie. Featuring gorgeous yellow lilies, peach roses, orange gerberas, fuchsia carnations, and more, Floral Spectacular is filled to the brim with vibrant and colorful flowers. Having an existential crisis? The Office.īiiiiiiig podcast gal right here. Finicky Flowers Weddings, Murrieta, California. Need something to fall asleep to? The Office. They are committed to offering only the finest floral arrangements and gifts. I will drink an iced coffee even if it is -2 degrees outside Finicky Flowers is a family-owned and operated floral business that proudly serves the Murrieta, Temecula, and Wildomar areas. It was never a phase!!! Another nod to the biz name, too I love music! I can appreciate all kinds of it, but I lean into the alternative/punk rock genre most often. I'm an anime nerd! I got hooked on Dragon Ball Z as a kid and never stopped! Demon Slayer, Attack On Titan, and My Hero Academia are current favorites I am extremely passionate about animals/animal welfare. I have 2 dogs and 1 cat of my own, and I volunteer at local shelters and rescues whenever possible. Purchase artificial grass products for your Murrieta front yard to add a beautiful green, warming feel to your home. I continue to meet the best people I know because of flowers, and that's pretty freakin cool. ![]() But most of all, I love the connections that this "job" has helped me create with folks from all walks of life. I love taking care of something and watching it bloom, whether its my friends kids, my actual pack of dogs (its true, I got a lot of them) or finicky flowers that need babied in order to be their best. I love flowers, I love making things, I love working with my hands. ![]() 'Nice new clean hotel with great amenities: indoor pool, common area with computers an.' more. You know that phrase "If you do what you love, you'll never work a day in your life"? yeah, that. Holiday Inn Express & Suites Coffeyville. I can't believe I get to do what I love and call it work. (I actually wanted to be a vet, and then a Spanish teacher when I was growing up.) I call it that because this feels like a dream. The finger-like spadix pops out of a clasping spathe. I don't call it that because I always dreamed of being a florist. The plant produces green or purple, insignificant flowers with typical Anthurium-like structure. Thanks so much for being here! Im Ali, and this is my dream job. ![]() ![]() ![]() The youngest of eight boys from the south side of Boston, the Scout learned early how to problem solve with his fists. Location of Origin: Boston, Massachusetts, USA He is an excellent class for those looking to play independently while still contributing to the team when the opportunity arises, and acts as a high-skill class for those who want to stack the odds in their favour while still winning in fair combat. On offense, he is essential for pressuring the enemy to defend their objectives, and though he is less useful on defense, he is still able to punish players who push too far into allied quarters. Regardless, when his strengths are abused, and his weaknesses are managed, the Scout is one of the most powerful classes in the game, able to act as a deadly counter to enemies caught out of position and able to finish off injured enemies who are trying to run away. And the low accuracy of his weapons at range means he is effectively useless against enemy Sentry Guns, which have a habit of immediately killing him. His specialization in 1v1 combat also means he has little to no influence against large groups of enemies, and cannot act as an omnipresent threat in the same way the Heavy or Engineer is. ![]() Failing to manage this mobility means he will immediately die to a wayward enemy, especially when running down tight corridors and cramped rooms. He is by and large an "honest" class that wins by killing the enemy or running away, and success with the Scout relies on having exceptional aim while managing his mobility. He also doesn't have any exceptional tricks that can turn the tide of battle, such as the Pyro's airblast or the Demoman's stickybomb traps. The Scout's biggest downsides are his susceptibility to splash damage, lack of crowd control, uselessness against enemy buildings, and his predictability when his double jump is used up. This makes him an ideal class for taking risks and sacrificing himself for the good of the team, hoping to find payoffs that will allow his team to win, even when they don't always pay out. ![]() His speed allows him to pick and choose his battles, looking for openings in the enemy's defense to kill important classes (especially the Medic and Civilian), or finding the perfect opportunity to steal an objective. Despite having the lowest health in the game, his innate mobility means he can dodge and weave around space better than the enemy can control it. He has 125 health, 133% speed, and has double capture rate, meaning he is able to capture control points and push payload carts at twice the speed of all other classes. The Scout is an offensive class whose purpose is to deal massive damage at close range with minimal downtime, supplemented with the highest speed in the game and the unique ability to double jump. ![]() ![]() ![]() You can open files, install extensions, change the display languages, and output diagnostics through its options. The command-line interface lets you control how you launch the editor. Either way, the terminal starts off in the current project’s working directory if one is loaded, or from your home folder if no project is loaded. On Mac and Linux, it shows up as a Bash prompt. On Windows, this terminal shows up as the Command Prompt. VS Code comes with an integrated command-line terminal. Installing this Docker extension adds some helpful Docker tools, such as generating Docker files, Docker file IntelliSense, and even monitoring.
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